bioinformatics comparison of human lactate dehydrogenase5 as a new tumor marker candidate to lactate dehydrogenase1
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Lactate dehydrogenase isoenzymes a comparison of pyruvate-to-lactate and lactate-to-pyruvate assays.
Both assays are accepted reference methods for measurement of lactate dehydrogenase (LDH) activity (2-4). At pH 7.4, pyruvate -* lactate (P -* L) activity is about three times lactate -+ pyruvate (L P) activity, because equilibrium favors formation of lactate. Normal range for the P -* L assay is 130-265 spectrophotometric units at 25#{176} (3); normal range for the L P assay is 40-98 units at ...
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PURPOSE The diagnostic classification of disorders of consciousness is often challenging, particularly the distinction between epileptic and non-epileptic seizures. The aim of the study was to examine serum lactate as a diagnostic marker of transient loss of consciousness. METHOD Serum lactate levels in blood samples drawn within 2h of the event were compared retrospectively between patients ...
متن کاملLactate – a Marker for Sepsis and Trauma
It is our pleasure to provide this EMCREG International newsletter which discusses lactate as a marker in resuscitation for sepsis and trauma. While lactate testing has been in medical arena for over a century, its utility in the emergency department for the evaluation of these potentially critically ill patients is only now being recognized. This newsletter aims to review the present literatur...
متن کامل[Blood lactate concentration as prognostic marker in critically ill children].
OBJECTIVE To assess the use of lactate as a marker of tissue hypoperfusion and as a prognostic index in critically ill patients. METHODS Prospective, longitudinal, observational study of 75 patients admitted to the pediatric ICU of Hospital de Clínicas of Universidade Federal do Paraná, between November 1998 and May 1999. According to the lactate level on admission, patients were divided into...
متن کاملLactate-to-pyruvate or pyruvate-to-lactate assay for lactate dehydrogenase: a re-examination.
The pyruvate-to-lactate assay for determining lactate dehydrogenase (EC 1.1.1.27) can now yield linearity equal to or better than that obtained by the lactate-to-pyruvate assay. In addition, there are significant advantages to the pyruvate-to-lactate reaction: (a) a greater change in absorbance per unit time, which allows more accurate spectrophotometric readout; (b) lower reactant concentratio...
متن کاملMetabolic Imaging: A link between Lactate Dehydrogenase A, Lactate and Tumor Phenotype Running title: A link between Lactate Dehydrogenase A and Lactate
Purpose: We compared the metabolic profiles and the association between LDH-A expression and lactate production in two isogenic murine breast cancer cell lines and tumors (67NR and 4T1). These cell lines were derived from a single mammary tumor and have different growth and metabolic phenotypes. Experimental Design: LDH-A expression, lactate concentration, glucose utilization and oxygen consump...
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عنوان ژورنال:
research in pharmaceutical sciencesجلد ۷، شماره ۵، صفحات ۰-۰
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